HCID 69583980, compound → HCID 21048984, compound

HRID 2212384Notes

Reaction equation

HRID 2212384 reaction equation
[CH2:1]([O:3][C:4](=[O:39])[CH:5]=[CH:6][C:7]1[CH:11]=[CH:10][O:9][C:8]=1[C:12](=[O:38])[CH2:13][CH:14]1[CH2:19][CH2:18][C:17]([S:28]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)(=[O:30])=[O:29])([C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])[CH2:16][CH2:15]1)[CH3:2]>[Rh].CO>[CH2:1]([O:3][C:4](=[O:39])[CH2:5][CH2:6][C:7]1[CH:11]=[CH:10][O:9][C:8]=1[C:12](=[O:38])[CH2:13][CH:14]1[CH2:19][CH2:18][C:17]([S:28]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)(=[O:29])=[O:30])([C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])[CH2:16][CH2:15]1)[CH3:2]

Participants

4

Reactant 1

HCID 69583980HCID 69583980, compound

Product 1

HCID 21048984HCID 21048984, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 887MethanolSolvent

Procedure

Rhodium on carbon catalyst (15 mg) was added to a solution of the product from Example 145 (100 mg, 0.17 mmol) in methanol (30 mL) and the reaction hydrogenated at 30 psi for 4 hours. The mixture was then filtered through Celite® and evaporated to give an oil. (100 mg). MS (ES+) 579 ([MH]+).

Workup

  1. customthe reaction hydrogenated at 30 psi for 4 hours
  2. filtrationThe mixture was then filtered through Celite®
  3. customevaporated
  4. customto give an oil

Sources & evidence

ORD record
ord-932b6899445e4d278023b4098c93dcb2
Source dataset
uspto-grants-2006_09
Patent number
US07101895B2

Reaction notes

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