Allylamine → HCID 4257022, compound

Temperature

15 °C

Butyroyl chloride (194.7 g, 1.83 mol) in 1 L of tetrahydrofuran was added to a three neck round bottom flask equipped with a thermometer, stir bar, and dropping funnel. The contents of the flask were then cooled to 15° C. in an ice bath while stirring. Allylamine (208.7 g, 3.65 mol) in 50 mL of tetrahydrofuran was then added slowly through the dropping funnel while maintaining stirring. Throughout the addition, the temperature was maintained at 15° C. After addition was complete, stirring continued for an additional 15 minutes, after which the solid allylamine chloride precipitate was filtered off. The filtrate was concentrated under vacuum to yield 236.4 g of N-allyl butyramide as a colorless viscous liquid.

1. customequipped with a thermometer
2. stirringwhile stirring
3. temperaturewhile maintaining
4. stirringstirring
5. additionThroughout the addition
6. temperaturethe temperature was maintained at 15° C
7. additionAfter addition
8. stirringstirring
9. filtrationafter which the solid allylamine chloride precipitate was filtered off
10. concentrationThe filtrate was concentrated under vacuum

ORD record

ord-a1321587822d4f7e8e1847110aaf7334

Source dataset

uspto-grants-2006_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07101960B2