1,1-Dimethoxyethyl(dimethyl)amine → HCID 178463640, compound

HRID 2212872Notes

Reaction equation

[NH2:1][C:2]1[S:3][C:4]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:14]=2)=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.CO[C:28](OC)([N:30]([CH3:32])[CH3:31])[CH3:29]>CN(C)C=O>[CH3:31][N:30]([CH3:32])[CH:28]([N:1]=[C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:4]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:14]=2)[S:3]1)[CH3:29]

Participants

Conditions

Temperature: 140 °C

Procedure

A suspension of [4-(2-amino-4-phenyl-thiazol-5-yl)-pyrimidin-2-yl]-phenyl-amine (0.28 g, 0.81 mmol) in dimethylacetamide dimethylacetal (0.22 g, 1.62 mmol) and dimethylformamide (10 ml) is heated at 140° C. for 4 hours. After distilling off all volatile compounds the residue is purified by chromatography on silicagel (eluent: ethyl acetate/hexane) to give in form of a yellow powder, m.p. 196–197° C.

Workup

distillationAfter distilling off all volatile compounds the residue
customis purified by chromatography on silicagel (eluent: ethyl acetate/hexane)
customto give in form of a yellow powder, m.p. 196–197° C.

Sources & evidence

ORD record: ord-74961d87419740728f2606ea9be77b3f
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07105517B2

Reaction notes

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