反应详情

A mixture of compound 4 (3.5 g, crude material), morpholine (0.99 g), potassium carbonate (2.89 g), and potassium iodide (1.66 g) in DMF (22 mL) was stirred at room temperature overnight. The reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (3×30 mL). The combined organic extracts were washed with brine (30 mL), dried over sodium sulfate, and concentrated to a residue. The crude material was purified by flash chromatography (silica gel, 30-50% ethyl acetate/hexanes) to yield compound 5 as a yellow solid.

1. extractionextracted with ethyl acetate (3×30 mL)
2. washThe combined organic extracts were washed with brine (30 mL)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated to a residue
5. customThe crude material was purified by flash chromatography (silica gel, 30-50% ethyl acetate/hexanes)