Trifluoroacetic acid → HCID 21955290, compound

HRID 2213054Notes

Reaction equation

HRID 2213054 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][C:5]=12.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21955306tert-Butyl 5,6-dihydroimidazo(1,2-a)pyrazine-7(8H)-carboxylate

Product 1

HCID 21955290HCID 21955290, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-Dimethylethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-carboxylate (Description 163, 505 mg, 2.26 mmol) in dichloromethane (2.5 mL) was added to stirred, cooled (0° C.) trifluoroacetic acid (5 mL) and the mixture was stirred at 0° C. for 15 minutes, then at room temperature for 45 minutes. The solvent was evaporated under reduced pressure to give the title compound. m/z (ES+) 124 (M+1).

Workup

  1. stirringthe mixture was stirred at 0° C. for 15 minutes
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-48b78878247741ff961ec000ecb7ef25
Source dataset
uspto-grants-2006_09
Patent number
US07105507B2

Reaction notes

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