Hydrochloric Acid → HCID 21955396, compound

HRID 2213147Notes

Reaction equation

HRID 2213147 reaction equation
[C:1]([O:5][C:6](=[O:31])[CH2:7][CH:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12](=[O:19])[N:11]([CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])[C:10]2[CH:27]=[CH:28][CH:29]=[CH:30][C:9]1=2)([CH3:4])([CH3:3])[CH3:2].[Li+].[OH-].Cl.C(Cl)Cl>O1CCOCC1.O>[C:1]([O:5][C:6](=[O:31])[CH2:7][CH:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12](=[O:19])[N:11]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])[C:10]2[CH:27]=[CH:28][CH:29]=[CH:30][C:9]1=2)([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 6344DichloromethaneHCID 21955415HCID 21955415, compound

Product 1

HCID 21955396HCID 21955396, compound

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

Ethyl 3-[11-(2-tert-butoxy-2-oxoethyl)-6-oxo-6,11-dihydro-5-H-dibenzo[b,e]azepin-5-yl]propanoate 5 (2.55 g, 6.02 mmol) was dissolved in 15 ml of 2:1 dioxane/H2O and, after addition of 0.17 g of LiOH, stirred at RT. After the reaction was complete, the mixture was acidified with 2N HCl and, after addition of CH2Cl2, washed with saturated NaCl solution, dried and concentrated.

Workup

  1. washwashed with saturated NaCl solution
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-093c313c00444b609ad689a0d93eb484
Source dataset
uspto-grants-2006_09
Patent number
US07105508B1

Reaction notes

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