Water → HCID 178516905, compound

HRID 2214434Notes

Reaction equation

HRID 2214434 reaction equation
[N:1]([O-:3])=[O:2].[Na+].Cl[C:6]1[C:7](=[O:24])[N:8]([CH2:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)[N:9]=[CH:10][C:11]=1Cl.[OH2:25]>CN(C)C=O>[OH:25][C:6]1[C:7](=[O:24])[N:8]([CH2:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)[N:9]=[CH:10][C:11]=1[N+:1]([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 962WaterHCID 2470061HCID 2470061, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 178516905HCID 178516905, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
85 °C

Procedure

A solution of 11.04 g (160 mmol) of sodium nitrite in 40 ml of water was added to a solution of 12 g (39.3 mmol) of 4,5-dichloro-2-naphthalen-1-ylmethyl-2H-pyridazin-3-one in 120 ml of dimethylformamide and the mixture was stirred for 24 hours at 85° C.

Sources & evidence

ORD record
ord-daabfef70cdd44a88ca1827ddfdeccca
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

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