O-Methylhydroxylamine hydrochloride → HCID 12146882, compound

HRID 2214549Notes

Reaction equation

HRID 2214549 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.Cl.[O:12]([NH2:14])[CH3:13].C([BH3-])#N.[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH:14][O:12][CH3:13]

Participants

4

Reactant 3

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 5938663-Chloro-4-fluorobenzaldehydeHCID 5003444Sodium cyanoborohydride

Product 1

HCID 12146882HCID 12146882, compound

Procedure

Reaction of 3-chloro-4-fluorobenzaldehyde with methoxylamine hydrochloride followed by reduction with sodium cyanoborohydride as described in the preparation of Compound 44-A and 44-B gave the title hydroxylamine as a clear oil. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.48 (3H, s), 3.98 (2H, s), 5.72 (1H, broad s), 7.10 (1H, t), 7.22 (1H, m), 7.42 (1H, m).

Sources & evidence

ORD record
ord-548d0e071a6a4ebbbdc5617b8b1103bb
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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