Formaldehyde → HCID 54704688, compound

HRID 2214676Notes

Reaction equation

HRID 2214676 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[S:20]([CH3:23])(=[O:22])=[O:21])[CH3:11])=[O:9])[C:4](=[O:24])O1.[CH2:26]=O.[N:28]1([CH2:34][CH2:35][NH2:36])[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([CH2:12][N:10]([CH3:11])[C:8]([C:7]2[CH2:26][N:36]([CH2:35][CH2:34][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[C:4](=[O:24])[C:5]=2[OH:6])=[O:9])=[C:14]([S:20]([CH3:23])(=[O:21])=[O:22])[CH:15]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 4082852-MorpholinoethylamineHCID 69656458HCID 69656458, compound

Product 1

HCID 54704688HCID 54704688, compoundYield 69%

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-2-methanesulfonyl-benzyl)-N-methyl-acetamide was reacted with paraformaldehyde and 2-morpholin-4-yl-ethylamine as described in Method 44B to give the title compound as a white solid (0.032 g, 69% yield). 1HNMR (300 MHz, DMSO) δ: 9.65 (1H, bs), 7.74 (1H, dd, J=8.41, 2.56 Hz), 7.64–7.59 (1H, m), 7.43–7.38 (1H, m), 4.99 (2H, s), 4.15 (2H, s), 4.00–3.53 (10H, m), 3.43 (2H, s), 3.38 (3H, s), 3.11 (3H, s).

Sources & evidence

ORD record
ord-a3e67adb132f488a89002fa7a47f87c2
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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