反应详情

To a solution of 5-amino-1,3,4-thiadiazole-2-thiol (0.6 g., 0.0045 mol) in dimethylformamide (25 mL) was added potassium carbonate (1.0 g, 0.0076 mol). The mixture was stirred for 1 hour at room temperature after which (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(triphenylmethoxyimino]acetamido]-3-chloro-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate diphenylmethyl ester (3.2 g., 0.0039 mol) was added. Stirring was continued for 18 hours. The mixture was partitioned between ethyl acetate (50 mL) and water (50 mL). The organic layer was separated, washed with water (30 mL), dried over anhydrous MgSO4 and the solvent was removed with a rotary evaporator. The resultant thick oil was treated with diethyl ether (50 mL) and the solid which formed was filtered and dried to give 2.6 g of crude product.

1. additionwas added
2. customThe mixture was partitioned between ethyl acetate (50 mL) and water (50 mL)
3. customThe organic layer was separated
4. washwashed with water (30 mL)
5. dry with materialdried over anhydrous MgSO4
6. customthe solvent was removed with a rotary evaporator
7. additionThe resultant thick oil was treated with diethyl ether (50 mL)
8. customthe solid which formed
9. filtrationwas filtered
10. customdried