HRID2214828

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：C=Cc1ccc(S(=O)(=O)N2CCN(CC3(NC(=O)OCC)CCN(c4ccnc(C)c4)CC3)C(=O)C2)cc1

HCID10143653

未命名化合物

PRODUCTS

生成物

结构：C=Cc1ccc(S(=O)(=O)N2CCN(CC3(NC(=O)OCC)CCN(c4ccnc(C)c4)CC3)C(=O)C2)cc1.Cl

HCID21948303

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

1-{[4-Ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidinyl]methyl}-4-(4-vinylbenzenesulfonyl)-2-piperazinone (86 mg) was suspended in ethyl acetate (10 ml), a 4N hydrochloric acid solution in ethyl acetate (0.3 ml) was added, and the resulting crystals were filtered off to obtain the title compound (38 mg) as colorless powders.

WORKUP

后处理

filtrationthe resulting crystals were filtered off

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9087d6bca24748aa8c9c1cdea4c50c99
来源数据集: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07109200B2
来源说明: uspto-grants-2006_09

反应 SMILES

[CH2:1]([O:3][C:4]([NH:6][C:7]1([CH2:20][N:21]2[CH2:26][CH2:25][N:24]([S:27]([C:30]3[CH:35]=[CH:34][C:33]([CH:36]=[CH2:37])=[CH:32][CH:31]=3)(=[O:29])=[O:28])[CH2:23][C:22]2=[O:38])[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=2)[CH2:9][CH2:8]1)=[O:5])[CH3:2].[ClH:39]>C(OCC)(=O)C>[ClH:39].[CH2:1]([O:3][C:4]([NH:6][C:7]1([CH2:20][N:21]2[CH2:26][CH2:25][N:24]([S:27]([C:30]3[CH:35]=[CH:34][C:33]([CH:36]=[CH2:37])=[CH:32][CH:31]=3)(=[O:28])=[O:29])[CH2:23][C:22]2=[O:38])[CH2:8][CH2:9][N:10]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=2)[CH2:11][CH2:12]1)=[O:5])[CH3:2]