Hydrochloric Acid → HCID 21947752, compound

HRID 2215152Notes

Reaction equation

HRID 2215152 reaction equation
[CH3:1][C:2]1[N:3]([C:8]2[C:17]([CH3:18])=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][C:9]=2[CH3:19])[C:4]([CH3:7])=[CH:5][CH:6]=1.[OH-].[Na+].Cl.O>C(O)C.C(OCC)(=O)C>[CH3:7][C:4]1[N:3]([C:8]2[C:9]([CH3:19])=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:16][C:17]=2[CH3:18])[C:2]([CH3:1])=[CH:6][CH:5]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 21947995HCID 21947995, compound

Product 1

HCID 21947752HCID 21947752, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Methyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)-3,5-dimethylbenzoate of Step A (1.55 g, 6 mmol) was dissolved in ethanol (100 mL) and treated with 1M sodium hydroxide (9 mL). The solution was refluxed overnight, cooled to room temperature, acidified with 1N hydrochloric acid, and diluted into water and ethyl acetate. The organic layer was washed with water until neutral, dried with anhydrous sodium sulfate, filtered and evaporated in vacuo to yield the title compound as a a cream colored solid (1.36 g).

Workup

  1. temperatureThe solution was refluxed overnight
  2. washThe organic layer was washed with water until neutral,
  3. dry with materialdried with anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-0be67271377a45b995c16742d3c9447b
Source dataset
uspto-grants-2006_09
Patent number
US07109193B2

Reaction notes

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