反应详情

Triethylamine (12.8 mL, 91.8 mmol) was added to a solution of 4-chloro-3-nitroquinoline (8.0 g, 38 mmol) in DMF (100 mL). The resulting solution was stirred for five minutes at room temperature, and then ethyl 3-aminobutyrate (6.2 mL, 42 mmol) was added. The reaction was stirred overnight at room temperature and poured into deionized water (320 mL). The mixture was extracted with ethyl acetate (1×125 mL and 2×100 mL). The combined extracts were washed with brine (3×120 mL), dried over magnesium sulfate, filtered through a layer of CELITE filter agent, concentrated under reduced pressure, and further dried under high vacuum to provide 11.5 g of ethyl 3-[(3-nitroquinolin-4-yl)amino]butanoate as a yellow solid.

1. stirringThe reaction was stirred overnight at room temperature
2. extractionThe mixture was extracted with ethyl acetate (1×125 mL and 2×100 mL)
3. washThe combined extracts were washed with brine (3×120 mL)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered through a layer of CELITE filter agent
6. concentrationconcentrated under reduced pressure
7. customfurther dried under high vacuum