Potassium Carbonate → HCID 21952671, compound

HRID 2215903Notes

Reaction equation

HRID 2215903 reaction equation
C(OC([N:8]1[CH2:26][CH2:25][CH:11]2[N:12]([CH3:24])[C:13]3[C:14]([C:20]([F:23])([F:22])[F:21])=[CH:15][C:16]([OH:19])=[CH:17][C:18]=3[CH:10]2[CH2:9]1)=O)(C)(C)C.Br[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH3:24][N:12]1[C:13]2[C:14]([C:20]([F:21])([F:23])[F:22])=[CH:15][C:16]([O:19][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:17][C:18]=2[CH:10]2[CH2:9][NH:8][CH2:26][CH2:25][CH:11]12

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5642092-(Bromomethyl)pyridineHCID 21056735HCID 21056735, compound

Product 1

HCID 21952671HCID 21952671, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

8-Hydroxy-5-methyl-6-trifluoromethyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (1.0 eq.), bromomethylpyridine (2.0 eq.), and K2CO3 (4.0 eq.) were dissolved in anhydrous DMF(0.3 M). The mixture was stirred under Ar at rt for 24 h. Same work up and deprotection procedure were followed as described in Example 74 Method A and B to obtain the title compound.

Sources & evidence

ORD record
ord-946b28963c0842439b6db819b3aeebe1
Source dataset
uspto-grants-2006_09
Patent number
US07109339B2

Reaction notes

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