反应详情

To a mixture of 5.35 g of 2-benzyl-6-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]pyridine and 40 ml of tetrahydrofuran was added dropwise 800 mg of oily (60%) sodium hydride gradually under stirring, and the mixture was stirred as it was for 1 hour. Then, 1.24 ml of methyl iodide was added thereto and the resultant mixture was stirred overnight as it was. The reaction mixture was extracted with ethyl acetate-water, and the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was purified by silica gel column chromatography (30% ethyl acetate/hexane), to give 2.18 g of the title compound.

1. stirringthe mixture was stirred as it
2. extractionThe reaction mixture was extracted with ethyl acetate-water
3. washthe organic layer was washed with water and brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customevaporated
6. customThe residue was purified by silica gel column chromatography (30% ethyl acetate/hexane)