反应详情

To a mixture of 3.11 g of 2-benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridine and 10 ml of N,N-dimethylformamide, while stirring in an ice bath, was added dropwise 2.5 g of N-iodosuccinimide, and the resultant mixture was stirred overnight as it was. To this was added sodium sulfite and the reaction mixture was extracted with ethyl acetate-water, and the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was purified by silica gel column chromatography (30% ethyl acetate/hexane), to give 4.19 g of the title compound.

1. extractionthe reaction mixture was extracted with ethyl acetate-water
2. washthe organic layer was washed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customevaporated
5. customThe residue was purified by silica gel column chromatography (30% ethyl acetate/hexane)