反应详情

10.1 g of 2-benzyl-1-hydroxy-4-iodobenzene and 3 ml of chloromethyl methyl ether were added to 100 ml of tetrahydrofuran and while stirring on an ice bath, 1.45 g of 60% (oily) sodium hydride was added dropwise to the mixture. After stirring for 2 hours, water was added to the reaction mixture, which then was extracted with ethyl acetate, washed with saturated brine and thereafter dried over anhydrous magnesium sulfate. The solvent was removed, and the residue was purified by silica gel column chromatography with 10% ethyl acetate/hexane, to give 8.7 g of the title compound.

1. stirringAfter stirring for 2 hours
2. extractionthen was extracted with ethyl acetate
3. washwashed with saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was removed
6. customthe residue was purified by silica gel column chromatography with 10% ethyl acetate/hexane