Trifluoroacetic acid → HCID 21942300, compound

HRID 2216351Notes

Reaction equation

HRID 2216351 reaction equation
[CH2:1]([C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][C:15]2=[O:19])[CH:11]=[CH:10][C:9]=1[O:20]COC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[CH2:1]([C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][C:15]2=[O:19])[CH:11]=[CH:10][C:9]=1[OH:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21942295HCID 21942295, compound

Product 1

HCID 21942300HCID 21942300, compoundYield 73.8%

Procedure

A mixture of 505 mg of 2-benzyl-1-methoxymethyloxy-4-(2-pyrrolidinon-1-yl)benzene and 5 ml of trifluoroacetic acid was stirred at room temperature for 1 hour. The reaction mixture was evaporated, and the residue was purified by silica gel column chromatography with 30–60% ethyl acetate/hexane, to give 320 mg of the title compound.

Workup

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified by silica gel column chromatography with 30–60% ethyl acetate/hexane

Sources & evidence

ORD record
ord-f3733ac3a6034053843521419ffa465f
Source dataset
uspto-grants-2006_09
Patent number
US07112593B2

Reaction notes

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