Ethyl Acetate → HCID 86591773, compound

HRID 2216358Notes

Reaction equation

HRID 2216358 reaction equation
[O:1]1[C@H:3]([CH2:4][OH:5])[C@@H:2]1[CH2:6][OH:7].C(OCC)(=O)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>C(N(CC)CC)C>[CH3:14][S:15]([O:7][CH2:6][C@H:2]1[C@@H:3]([CH2:4][O:5][S:15]([CH3:14])(=[O:17])=[O:16])[O:1]1)(=[O:17])=[O:16]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 31297Methanesulfonyl chlorideHCID 64534592,3-Anhydroerythritol

Product 1

HCID 86591773HCID 86591773, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a mixture of 2.3 g of cis-oxirane-2,3-dimethanol and 200 ml of ethyl acetate was added 9.3 ml of triethylamine and then 4.3 ml of methanesulfonyl chloride under ice-cooling, followed by stirring at the same temperature for 4 hours. The reaction mixture was filtered through silica gel and washed with ethyl acetate. Thereafter, the filtrate was evaporated, to give 5.4 g of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered through silica gel
  2. washwashed with ethyl acetate
  3. customThereafter, the filtrate was evaporated

Sources & evidence

ORD record
ord-be5fa124727449acbf98f13501895e12
Source dataset
uspto-grants-2006_09
Patent number
US07112593B2

Reaction notes

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