反应详情

温度

110 °C

A mixture of 5.4 g of cis-2,3-bis(methanesulfonyloxymethyl)oxirane, 2 ml of 3-bromoaniline, 4.3 g of anhydrous potassium carbonate and 30 ml of N,N-dimethylformamide was stirred under nitrogen atmosphere at 60° C. for 2 hours and at 110° C. for 2 hours. The reaction mixture was extracted with ethyl acetate-water, and the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and then evaporated. The residue was purified by silica gel column chromatography with 5–10% ethyl acetate/hexane, to give 420 mg of the title compound.

1. extractionThe reaction mixture was extracted with ethyl acetate-water
2. washthe organic layer was washed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customevaporated
5. customThe residue was purified by silica gel column chromatography with 5–10% ethyl acetate/hexane