1-Piperazinecarboxylic acid, ethyl ester → 1-(Oxan-4-yl)piperazine

HRID 2216393Notes

Reaction equation

HRID 2216393 reaction equation
C(O[C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=O)C.[O:12]1[CH2:17][CH2:16]C(=O)[CH2:14][CH2:13]1>>[O:12]1[CH2:17][CH2:16][CH:4]([N:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]2)[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 121599Tetrahydro-4H-pyran-4-one

Product 1

HCID 219423151-(Oxan-4-yl)piperazineYield 39%

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 10 using 1-ethoxycarbonylpiperazine (50 g) and 2,3,5,6-tetrahydropyran-4-one (34 g), the title compound (21 g) was obtained. boiling point: 95-100° C./5 mmHg

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-fd2ef17b5cfd485a8d92e094603fa3c0
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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