Lithium hydroxide, monohydrate → HCID 69307433, compound

HRID 2217265Notes

Reaction equation

HRID 2217265 reaction equation
[NH2:1][C:2]1[C:16]([Br:17])=[CH:15][C:5]([C:6]([C@@H:8]2[CH2:10][C@H:9]2[C:11]([O:13]C)=[O:12])=[O:7])=[CH:4][C:3]=1[Br:18].O.[OH-].[Li+].[K+].[Br-]>O.O1CCCC1>[NH2:1][C:2]1[C:3]([Br:18])=[CH:4][C:5]([C:6]([C@@H:8]2[CH2:10][C@H:9]2[C:11]([OH:13])=[O:12])=[O:7])=[CH:15][C:16]=1[Br:17]

Participants

5

Reactant 3

HCID 168937Lithium hydroxide, monohydrateHCID 253877Potassium BromideHCID 69306640HCID 69306640, compound

Product 1

HCID 69307433HCID 69307433, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

Prepared analogously to Example 2 from methyl trans-2-(4-amino-3,5-dibromobenzoyl)cyclopropanecarboxylate by saponification with lithium hydroxide hydrate in a water-tetrahydrofuran mixture (2/3 v/v) in a yield of 76% of theoretical. Colorless crystals. IR (KBr): 3473.2, 3345.9 (NH2); 1714.4 (C═O) cm−1.

Sources & evidence

ORD record
ord-d936a22b635c42768623b787c5c28336
Source dataset
uspto-grants-2008_08
Patent number
US07407963B2

Reaction notes

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