Trifluoroacetic acid → HCID 86601542, compound

HRID 2217486Notes

Reaction equation

HRID 2217486 reaction equation
C(OC([N:8]1[CH2:12][C@H:11]([O:13][Si](C(C)(C)C)(C)C)[CH2:10][C@@H:9]1[C:21](=[O:35])[NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29](=[O:33])[N:30]([CH3:32])[CH3:31])=[CH:25][C:24]=1[F:34])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:31][N:30]([CH3:32])[C:29]([C:26]1[CH:27]=[CH:28][C:23]([NH:22][C:21]([C@H:9]2[CH2:10][C@@H:11]([OH:13])[CH2:12][NH:8]2)=[O:35])=[C:24]([F:34])[CH:25]=1)=[O:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68807323HCID 68807323, compound

Product 1

HCID 86601542HCID 86601542, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Into a solution of 6 (0.33 g, 0.647 mmol) in anhydrous CH2Cl2 (10 mL) was added TFA (2 mL). The solution was stirred at RT for 4 h before concentrating under reduced pressure to give 7 (0.19 g, 100%).

Workup

  1. concentrationbefore concentrating under reduced pressure

Sources & evidence

ORD record
ord-cef345d74d4c46728e278a798fc71de0
Source dataset
uspto-grants-2008_08
Patent number
US07407972B2

Reaction notes

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