Hydrochloric Acid → Sodium Chloride

HRID 221794Notes

Reaction equation

HRID 221794 reaction equation
C[O:2][C:3]([C:5]1[C:10]([CH3:11])=[N:9][C:8]([O:12][CH3:13])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+:15].[ClH:16].C1(C)C=CC=CC=1>C1COCC1>[CH3:13][O:12][C:8]1[N:9]=[C:10]([CH3:11])[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1.[Cl-:16].[Na+:15]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 14798Sodium HydroxideHCID 66665775Methyl 5-methoxy-3-methylpyrazine-2-carboxylate

Product 2

HCID 5234Sodium ChlorideHCID 666658305-Methoxy-3-methylpyrazine-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 105 mg (0.577 mmol) 5-methoxy-3-methyl-pyrazine-2-carboxylic acid methyl ester in 2.6 ml THF was cooled to 0. ° C., 0.635 ml (0.635 mmol) 1N sodium hydroxide was added dropwise and the mixture was stirred at room temperature for 1.5 h. After re-cooling to 0° C. 0.635 ml (0.635 mmol) 1N HCl and 1.2 ml toluene were added and the solvents were evaporated to provide the title compound together with sodium chloride as brownish solid. The mixture was used for coupling reactions without further purification.

Workup

  1. temperatureAfter re-cooling to 0° C
  2. customthe solvents were evaporated

Sources & evidence

ORD record
ord-dfbf6081aa1640e4a86b930aa74d6f79
Source dataset
uspto-grants-2012_06
Patent number
US08207164B2

Reaction notes

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