反应详情

4-[(3-Furylmethyl)amino]-3-nitro-N,N-bis(2,2,2-trifluoroethyl)benzamide (108 mg, 0.254 mmol) was dissolved in 5 mL of DMF. Tin(II) chloride dihydrate (860 mg, 1.27 mmol) was added and the solution was stirred under nitrogen at RT for 24 h. The solvent was evaporated and the residue was taken up in EtOAc. The organic phase was washed with saturated NaHCO3 solution, brine and dried over anhydrous MgSO4. The crude product was used directly for the next step. Yield: 80 mg (80%); MS (ESI) 396.11 (MH+).

1. customThe solvent was evaporated
2. washThe organic phase was washed with saturated NaHCO3 solution, brine
3. dry with materialdried over anhydrous MgSO4