Phenylboronic Acid → HCID 11164299, compound

HRID 2218014Notes

Reaction equation

HRID 2218014 reaction equation
Cl[C:2]1[C:3]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:4]=2[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=1.C1(B(O)O)C=CC=CC=1.[Cl:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1B(O)O>>[Cl:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[C:2]1[C:3]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:4]=2[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=1

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 27343222-Chlorophenylboronic acidHCID 69289305HCID 69289305, compound

Product 1

HCID 11164299HCID 11164299, compoundYield 61%

Procedure

Prepared from 5-chloro-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one using the same method described for Example 9 and instead of using benzene boronic acid, we used 2-chlorophenyl boronic acid. The title compound (115 mg) was obtained as a beige solid, (yield=61%).

Sources & evidence

ORD record
ord-33c60f15a2a44bdeb385174337269031
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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