Tributylphosphine → HCID 58612387, compound

HRID 2218104Notes

Reaction equation

HRID 2218104 reaction equation
[Cl:1][CH2:2][CH2:3][C@H:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5].[S:12]1[C:20]2[C:15](=[N:16][CH:17]=[CH:18][C:19]=2O)[CH:14]=[CH:13]1.P(CCCC)(CCCC)CCCC>>[Cl:1][CH2:2][CH2:3][C@@H:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[O:5][C:19]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:14]=[CH:13][S:12][C:20]=12

Participants

4

Reactant 3

HCID 13831TributylphosphineHCID 642409(1R)-3-chloro-1-phenylpropan-1-olHCID 5074765Thieno[3,2-b]pyridin-7-ol

Product 1

HCID 58612387HCID 58612387, compoundYield 54%

Procedure

using (R)-(+)-3-chloro-1-phenyl-1-propanol, thieno[3,2-b]pyridin-7-ol (commercially available from the Aldrich Chemical Company), PBu3, and ADPP gave the title compound (0.71 g, 54%); Mass spectrum (ion spray): m/z=304.06 (m+1).

Sources & evidence

ORD record
ord-714621f6656c4ea1951b1aeb0f567513
Source dataset
uspto-grants-2008_08
Patent number
US07410982B2

Reaction notes

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