Urea → 3-(4-{2-Oxo-3-[4-(3-o-tolyl-ureido)phenyl]piperidin-1-yl}phenyl)propionic acid

HRID 2218134Notes

Reaction equation

HRID 2218134 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=3)[C:14]2=[O:28])=[CH:9][CH:8]=1)C.[NH2:30][C:31](N)=[O:32]>>[O:28]=[C:14]1[CH:15]([C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:31]([NH:30][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[CH3:6])=[O:32])=[CH:21][CH:20]=2)[CH2:16][CH2:17][CH2:18][N:13]1[C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:3])=[O:29])=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 1176UreaHCID 693003343-{4-[3-(4-Nitrophenyl)-2-oxo-2H-pyridin-1-yl]phenyl}propionic acid ethyl ester

Product 1

HCID 104798883-(4-{2-Oxo-3-[4-(3-o-tolyl-ureido)phenyl]piperidin-1-yl}phenyl)propionic acid

Procedure

The title compound was prepared from 3-{4-[3-(4-nitrophenyl)-2-oxo-2H-pyridin-1-yl]phenyl}propionic acid ethyl ester which is prepared as described in Preparation 24 with subsequent hydrogenation, urea formation, and hydrolysis steps analogous to the procedures of Preparation 23, Preparation 9 and Example 1 respectively.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-b81abd9acd0a40c2970d469425798c38
Source dataset
uspto-grants-2008_08
Patent number
US07410984B2

Reaction notes

Loading…