Methylamine → 3-[4-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]propan-1-amine

HRID 2218363Notes

Reaction equation

HRID 2218363 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:31]=[CH:30][C:14]([O:15][CH2:16][CH2:17][CH2:18][N:19]4C(=O)C5C(=CC=CC=5)C4=O)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1.CN>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:31]=[CH:30][C:14]([O:15][CH2:16][CH2:17][CH2:18][NH2:19])=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178514999HCID 178514999, compound

Product 1

HCID 1785111463-[4-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]propan-1-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared by stirring 2-{3-[4-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]propyl}-1H-isoindole-1,3(2H)-dione with a large excess of methylamine in ethanol for two days and was purified by column chromatography on silica.

Workup

  1. customwas purified by column chromatography on silica

Sources & evidence

ORD record
ord-43569341b3ee48ef8df558257f13879a
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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