HCID 178427949, compound → HCID 178427948, compound

HRID 2218411Notes

Reaction equation

HRID 2218411 reaction equation
[Cl:1][C:2]1[C:3]([CH3:32])=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][CH2:18][C@H:19]4[CH2:23][CH2:22][CH2:21][N:20]4C(OC(C)(C)C)=O)=[C:13]([OH:31])[CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1>ClCCl.FC(F)(F)C(O)=O>[Cl:1][C:2]1[C:3]([CH3:32])=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][CH2:18][C@H:19]4[CH2:23][CH2:22][CH2:21][NH:20]4)=[C:13]([OH:31])[CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 1

HCID 178427949HCID 178427949, compound

Product 1

HCID 178427948HCID 178427948, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl (2R)-2-([{4-(6-chloro-7-methyl-3H-imidazo[4,5-b]pyridin-2-yl)-2-hydroxyphenyl]amino}methyl)pyrrolidine-1-carboxylate (Example 250a) (0.017 g, 0.037 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1 ml). After 3 h, the reaction mixture was evaporated and the residue was purified by HPLC-C18, giving the title product as a bis(trifluoroacetate) (0.012 g, 55%).

Workup

  1. customthe reaction mixture was evaporated
  2. customthe residue was purified by HPLC-C18

Sources & evidence

ORD record
ord-380febcb445744f2b7fd7cd12c7d4e5c
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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