Hydrochloric Acid → HCID 43137877, compound

HRID 2218527Notes

Reaction equation

HRID 2218527 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[N:6]=[C:7]([NH:10]C(=O)C)[S:8][CH:9]=1)[CH3:2].Cl>C1COCC1>[CH2:1]([O:3][CH2:4][C:5]1[N:6]=[C:7]([NH2:10])[S:8][CH:9]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86606419HCID 86606419, compound

Product 1

HCID 43137877HCID 43137877, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To N-(4-ethoxymethyl-thiazol-2-yl)-acetamide (35 mg, 0.175 mmol) in THF (2 ml) was added 6N HCl (2 ml). The reaction was heated at 60° C. for 4 hours, stirred at room temperature overnight and then heated at 60° C. for additional 3 hours. The solution was concentrated to afford 4-ethoxymethyl-thiazol-2-ylamine as a viscous yellow oil (22 mg, 65% ). LC/MS m/z 159.05 (M+1)+; HPLC Rt: 0.34 min.

Workup

  1. temperatureheated at 60° C. for additional 3 hours
  2. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-809b5d77ee7445bc8aee68f856126822
Source dataset
uspto-grants-2008_08
Patent number
US07411071B2

Reaction notes

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