Potassium Carbonate → HCID 23073291, compound

HRID 2218550Notes

Reaction equation

HRID 2218550 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[F:9].[OH:10][C:11]1[C:18]([CH3:19])=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[CH3:20].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][O:10][C:11]1[C:12]([CH3:20])=[CH:13][C:14]([CH:15]=[O:16])=[CH:17][C:18]=1[CH3:19]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67968alpha-Bromo-o-fluorotolueneHCID 752223,5-Dimethyl-4-hydroxybenzaldehyde

Product 1

HCID 23073291HCID 23073291, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

0.5 M Solution of 1-bromomethyl-2-fluoro-benzene (1.51 g, 8.0 mmol) in DMF was added dropwise to a suspension containing 1.1 g of 4-hydroxy-3,5-dimethyl-benzaldehyde (7.3 mmol), 1.51 g of K2CO3 (11 mmol) and 120 mg of KI (0.73 mmol) in 100 ml DMF. The reaction followed the same procedure described in Example 3. The residue was purified on silica gel, obtaining a quantitative recovery of the title compound. (1.88 g).

Workup

  1. customThe residue was purified on silica gel

Sources & evidence

ORD record
ord-a54f566f7a67458b98bfb967e9464fe4
Source dataset
uspto-grants-2008_08
Patent number
US07411091B2

Reaction notes

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