反应详情

Dissolve 2-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-benzonitrile (100 mg, 0.32 mmol) in DMSO (3 mL) and add solid K2CO3 (50 mg) followed by 30% H2O2 (100□1). Stir the reaction for 3 h. and quench by pouring into water. Collect the white solid and dry in a vacuum oven to yield 84 mg (81%). 1H NMR (DMSO-d6) δ2.95 (br s, 2H), 3.38 (br s, 2H), 6.67-7.56 (m, 12H), 7.90 (s, 1H); MS (ES) 326 (M+1) (M−1). HPLC shows 95% purity.

1. customthe reaction for 3 h.
2. customquench
3. additionby pouring into water
4. customCollect the white solid
5. customdry in a vacuum oven
6. customto yield 84 mg (81%)