Trifluoroacetic acid → HCID 22999484, compound

HRID 2218939Notes

Reaction equation

HRID 2218939 reaction equation
C([O:5][C:6](=[O:31])[CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][N:16]([CH2:21][CH2:22][NH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[C:15]2=[O:30])=[O:11])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:30]=[C:15]1[C:14]2[C:18](=[CH:19][CH:20]=[C:12]([C:10]([NH:9][CH2:8][CH2:7][C:6]([OH:31])=[O:5])=[O:11])[CH:13]=2)[CH2:17][N:16]1[CH2:21][CH2:22][NH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69178162HCID 69178162, compound

Product 1

HCID 22999484HCID 22999484, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the ester (8) (252 mg, 0.60 mmol), TFA (4 ml) and CH2Cl2 (8 ml) was stirred at ambient temperature for 3 hours. The mixture was evaporated to dryness and the residue purified by flash chromatography (silica, EtOH/NH4OH 19:1) to provide (9) as off-white foam. NMR conforms to structure.

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe residue purified by flash chromatography (silica, EtOH/NH4OH 19:1)

Sources & evidence

ORD record
ord-c1bf01c63b7d447e9c2141cb7772db36
Source dataset
uspto-grants-2008_08
Patent number
US07413727B2

Reaction notes

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