Hydrochloric Acid → HCID 68974653, compound

HRID 2219021Notes

Reaction equation

HRID 2219021 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:14][N:13]([CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])[C:12]2[CH:22]=[CH:23][CH:24]=[CH:25][C:11]=2[NH:10][C:9]1=[O:26])(C)(C)C.[ClH:28]>O1CCOCC1>[ClH:28].[NH2:7][C@@H:8]1[C:9](=[O:26])[NH:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[N:13]([CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718672HCID 59718672, compound

Product 1

HCID 68974653HCID 68974653, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous procedure to that described in Example 1d), the treatment of the [(S)-4-oxo-1-(4,4,4-trifluoro-butyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester with hydrochlorid acid (37%) in dioxane yielded the title compound as a light yellow solid; MS (m/e): 288 (M+H)+.

Sources & evidence

ORD record
ord-8a5baf9c0b934a65a1019620aeac72cf
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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