Hydrochloric Acid → HCID 25242115, compound

HRID 2219022Notes

Reaction equation

HRID 2219022 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:14][N:13]([CH2:15][CH2:16][O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:12]2[CH:25]=[CH:26][CH:27]=[CH:28][C:11]=2[NH:10][C:9]1=[O:29])(C)(C)C.[ClH:31]>O1CCOCC1>[ClH:31].[NH2:7][C@@H:8]1[C:9](=[O:29])[NH:10][C:11]2[CH:28]=[CH:27][CH:26]=[CH:25][C:12]=2[N:13]([CH2:15][CH2:16][O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718700HCID 59718700, compound

Product 1

HCID 25242115HCID 25242115, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the [(S)-1-(2-benzyloxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester with hydrochlorid acid (37%) in dioxane yielded the title compound as a light yellow foam; MS (m/e): 312 (M+H)+.

Sources & evidence

ORD record
ord-c3c9f1e2151a4793af1473b0b01b100d
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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