Hydrochloric Acid → HCID 68973979, compound

HRID 2219031Notes

Reaction equation

HRID 2219031 reaction equation
[F:1][C:2]([F:28])([F:27])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH:14]C(OC(C)(C)C)=O)[C:11](=[O:22])[NH:10][C:9]2[CH:23]=[CH:24][CH:25]=[CH:26][C:8]1=2)=[O:6].[ClH:29]>O1CCOCC1>[ClH:29].[F:28][C:2]([F:1])([F:27])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH2:14])[C:11](=[O:22])[NH:10][C:9]2[CH:23]=[CH:24][CH:25]=[CH:26][C:8]1=2)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718674HCID 59718674, compound

Product 1

HCID 68973979HCID 68973979, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the (S)-3-tert-butoxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 2,2,2-trifluoro-ethyl ester with hydrochlorid acid (37%) in dioxane yielded (98% of theory) the title compound as an off-white solid; MS (m/e): 304 (M+H)+.

Sources & evidence

ORD record
ord-b89b5ef1211048c982b5e93b3fdd6366
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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