Hydrochloric Acid → HCID 87692339, compound

HRID 2219032Notes

Reaction equation

HRID 2219032 reaction equation
[F:1][C:2]([F:33])([F:32])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH:14]C(OC(C)(C)C)=O)[C:11](=[O:22])[N:10]([CH2:23][C:24]([F:27])([F:26])[F:25])[C:9]2[CH:28]=[CH:29][CH:30]=[CH:31][C:8]1=2)=[O:6].[ClH:34]>O1CCOCC1>[ClH:34].[F:33][C:2]([F:1])([F:32])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH2:14])[C:11](=[O:22])[N:10]([CH2:23][C:24]([F:25])([F:26])[F:27])[C:9]2[CH:28]=[CH:29][CH:30]=[CH:31][C:8]1=2)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718711HCID 59718711, compound

Product 1

HCID 87692339HCID 87692339, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the (S)-3-tert-butoxycarbonylamino-4-oxo-5-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 2,2,2-trifluoro-ethyl ester [Example 10a)] with hydrochlorid acid (37%) in dioxane yielded (93% of theory) the title compound as a light yellow solid; MS (m/e): 386 (M+H)+.

Sources & evidence

ORD record
ord-0ed1178e07ac471b943faefa0efe93f9
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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