Hydrochloric Acid → HCID 68975256, compound

HRID 2219036Notes

Reaction equation

HRID 2219036 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][O:11][C:12]([N:14]1[CH2:20][C@H:19]([NH:21]C(OC(C)(C)C)=O)[C:18](=[O:29])[N:17]([CH2:30][CH2:31][O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:16]2[CH:40]=[CH:41][CH:42]=[CH:43][C:15]1=2)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:44]>O1CCOCC1>[ClH:44].[CH2:1]([O:8][CH2:9][CH2:10][O:11][C:12]([N:14]1[CH2:20][C@H:19]([NH2:21])[C:18](=[O:29])[N:17]([CH2:30][CH2:31][O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:16]2[CH:40]=[CH:41][CH:42]=[CH:43][C:15]1=2)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718702HCID 59718702, compound

Product 1

HCID 68975256HCID 68975256, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the (S)-5-(2-benzyloxy-ethyl)-3-tert-butoxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 2-benzyloxy-ethyl ester with hydrochlorid acid (37%) in dioxane yielded quantitatively the title compound as a viscous light yellow oil; MS (m/e): 490 (M+H)+.

Sources & evidence

ORD record
ord-744c2b9dcd824973b9e918987605a76f
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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