反应详情

Under a nitrogen stream, a mixture of 1-benzenesulfonyl-6-bromo-1H-indol-5-ylmethyl acetate (257 mg, 0.63 mmol), potassium carbonate (15 mg, 0.11 mmol) and methanol (4 mL) was stirred for 1 hour at room temperature. To the resultant mixture was added 2 N hydrochloric acid (0.11 mL), and solvent was then removed by distillation under reduced pressure. The resulting residue was purified by silica gel flash column chromatography (developing solution=ethyl acetate:n-hexane (2:1)), to thereby obtain the titled compound (225 mg, 97%).

1. customwas then removed by distillation under reduced pressure
2. customThe resulting residue was purified by silica gel flash column chromatography (developing solution=ethyl acetate:n-hexane (2:1))