Ethyl Acetate → HCID 67421314, compound

HRID 2219384Notes

Reaction equation

HRID 2219384 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][NH:16][CH:17]=3)=[C:11]([CH3:18])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:19]([O:21][C:22]([C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1)=[O:23])[CH3:20].C(OCC)(=O)C>CCCCCC>[CH2:19]([O:21][C:22](=[O:23])[C:24]1[CH:25]=[CH:26][CH:27]=[C:28]([N:14]2[C:13]([C:12]3[C:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=4)=[N:9][O:10][C:11]=3[CH3:18])=[CH:17][N:16]=[CH:15]2)[CH:29]=1)[CH3:20]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 3249312(3-Ethoxycarbonylphenyl)boronic acidHCID 178434992HCID 178434992, compound

Product 1

HCID 67421314HCID 67421314, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

As described for Example 3, 3-(3-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methyl-isoxazole (2.43 g, 10 mmol) was converted, using of 3-ethoxycarbonylphenylboronic acid instead of 4-fluorophenylboronic acid, through chromatography (SiO2, ethyl acetate: hexane=20:10) to the title compound (1.26 mg, 32%) which was obtained as a light yellow solid. MS: m/e=392.1 [M+H]+.

Sources & evidence

ORD record
ord-3e2da6132aba4b05a019aa8ed957e45b
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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