5-Bromopyrimidine → HCID 11717841, compound

HRID 2219487Notes

Reaction equation

HRID 2219487 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[N:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[CH:15][CH:14]=[C:13]([CH3:18])[N:12]=2)=[O:10])[S:6][CH:7]=1.Br[C:22]1[CH:23]=[N:24][CH:25]=[N:26][CH:27]=1>>[F:20][C:2]([F:19])([F:1])[C:3]1[N:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:22]3[CH:23]=[N:24][CH:25]=[N:26][CH:27]=3)=[CH:15][CH:14]=[C:13]([CH3:18])[N:12]=2)=[O:10])[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 783445-BromopyrimidineHCID 86607572HCID 86607572, compound

Product 1

HCID 11717841HCID 11717841, compound

Procedure

The title compound, light yellow solid, MS (ISP): m/e=381.0 (M+H+), was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-trifluoromethyl-thiazol-2-yl)-amide in accordance with the general method of example 20 using 5-bromopyrimidine instead of 3-bromo-pyridine.

Sources & evidence

ORD record
ord-bb400c23bb5b4fe8938783940ff6532c
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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