2-Amino-4-methylthiazole → 6-Methyl-3-(4-methyl-thiazol-2-ylamino)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

HRID 2219549Notes

Reaction equation

HRID 2219549 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[C:15](Br)=[CH:14][CH:13]=[C:12]([CH3:17])[N:11]=2)=[O:9])=[N:3]1.[NH2:18][C:19]1[S:20][CH:21]=[C:22]([CH3:24])[N:23]=1>>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[C:15]([NH:18][C:19]3[S:20][CH:21]=[C:22]([CH3:24])[N:23]=3)=[CH:14][CH:13]=[C:12]([CH3:17])[N:11]=2)=[O:9])=[N:3]1

Participants

3

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 866075903-Bromo-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Product 1

HCID 116312756-Methyl-3-(4-methyl-thiazol-2-ylamino)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Procedure

The title compound, was prepared from 3-Bromo-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide in accordance with the general method of Example 78, step 3 using 2-Amino-4-methylthiazole instead of 3-Amino-1-methyl-pyrazole to yield the final compound as a yellow solid, MS (ISP): m/e=329.1 (M+H+).

Sources & evidence

ORD record
ord-128604df8d6f413497e2cdd3d87560ae
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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