反应详情

温度

100 °C

To a solution of 3,4,5,6-tetrahydro-2-(1H)-pyrimidinone (4 g, 0.04 mol) in abs. DMF (50 mL) there were added potassium carbonate (5.5 g, approximately 0.04 mol), potassium iodide (3.3 g, 0.02 mol), and 4-nitrobenzyl bromide (8.6 g, 0.04 mol) at RT. The reaction mixture was stirred at 100° C. over a period of 2 h. Following cooling of the reaction mixture, it was added to ice water (500 mL). The precipitated solid matter was filtered off in vacuo and washed with a little acetyl (4×10 mL). The desired product 1-(4-nitrobenzyl)tetrahydropyrimidin-2-one (H) was obtained as yellow solid matter (3.5 g, 40% of theory) having a melting point of 150-162° C.

1. temperatureFollowing cooling of the reaction mixture, it
2. filtrationThe precipitated solid matter was filtered off in vacuo
3. washwashed with a little acetyl (4×10 mL)