2-Amino-5-methylthiazole → 6-Methyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (5-methyl-thiazol-2-yl)-amide

HRID 2219575Notes

Reaction equation

HRID 2219575 reaction equation
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[N:17][CH:18]=2)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[S:22][C:23]([CH3:26])=[CH:24][N:25]=1>>[CH3:26][C:23]1[S:22][C:21]([NH:20][C:4]([C:6]2[C:11]([NH:12][C:13]3[CH:18]=[N:17][CH:16]=[N:15][CH:14]=3)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])=[N:25][CH:24]=1

Participants

3

Reactant 2

HCID 3517702-Amino-5-methylthiazoleHCID 58368053Ethyl 6-methyl-3-(5-pyrimidinylamino)-2-pyridinecarboxylate

Product 1

HCID 116455576-Methyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (5-methyl-thiazol-2-yl)-amide

Procedure

The title compound, was prepared in accordance with the general method of Example 78, step 2 from 6-Methyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid ethyl ester and 2-Amino-5-methylthiazole to yield the final compound as a yellow crystalline solid, MS (ISP): m/e=327.1 (M+H+).

Sources & evidence

ORD record
ord-7ae697cfa1834b36b5bfabdaade68666
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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