Trimethylaluminum → HCID 131726997, compound

HRID 2219578Notes

Reaction equation

[Al](C)(C)C.C(O[C:8]([C:10]1[C:15]([NH:16][C:17]2[CH:18]=[N:19][CH:20]=[N:21][CH:22]=2)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=1)=[O:9])C.[C:24]([SiH2:28][O:29][C:30]([CH3:38])([CH3:37])[C:31]1[N:32]=[C:33]([NH2:36])[S:34][CH:35]=1)([CH3:27])([CH3:26])[CH3:25]>>[C:24]([SiH2:28][O:29][C:30]([CH3:38])([CH3:37])[C:31]1[N:32]=[C:33]([NH:36][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:22]=[N:21][CH:20]=[N:19][CH:18]=3)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])[S:34][CH:35]=1)([CH3:27])([CH3:25])[CH3:26]

Participants

Reactant 3

HCID 16682925Trimethylaluminum

HCID 58368053Ethyl 6-methyl-3-(5-pyrimidinylamino)-2-pyridinecarboxylate

HCID 131726998HCID 131726998, compound

Product 1

HCID 131726997HCID 131726997, compound

Procedure

The Al(Me)3-catalyzed reaction of 6-Methyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid ethyl ester and 4-(tert-Butyl-dimethyl-silanyloxymethyl)-thiazol-2-ylamine (CAS [752241-92-2]; WO2004076420) in accordance with the general method of Example 78, step 2 yielded the title compound as an off-white solid, MS (ISP): m/e=457.3 (M+H+).

Sources & evidence

ORD record: ord-9a8229392d694a2c8826d17cca34751c
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414060B2

Reaction notes

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