5-Bromopyrimidine → HCID 131727000, compound

HRID 2219582Notes

Reaction equation

HRID 2219582 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH2:16])=[CH:14][CH:13]=[C:12]([C:17]([CH3:25])([CH3:24])[O:18][SiH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])[N:11]=2)=[O:9])[S:5][CH:6]=1.Br[C:27]1[CH:28]=[N:29][CH:30]=[N:31][CH:32]=1>[Pd]>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:27]3[CH:28]=[N:29][CH:30]=[N:31][CH:32]=3)=[CH:14][CH:13]=[C:12]([C:17]([CH3:25])([CH3:24])[O:18][SiH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])[N:11]=2)=[O:9])[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 783445-BromopyrimidineHCID 131727001HCID 131727001, compound

Product 1

HCID 131727000HCID 131727000, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Palladium catalysed arylation of 3-Amino-6-(tert-butyl-dimethyl-silanyloxymethyl)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide with 5-Bromopyrimidine according to the general procedure described in example 4 step 4 yielded the title product as a light yellow solid, MS (ISP): m/e=457.3 (M+H+).

Sources & evidence

ORD record
ord-558c67c699c749c28629f4097dbf1fe5
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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