2-Amino-4-methylthiazole → HCID 11602545, compound

HRID 2219589Notes

Reaction equation

HRID 2219589 reaction equation
[Al](C)(C)C.C(O[C:8]([C:10]1[C:15]([NH:16][C:17]2[CH:18]=[N:19][CH:20]=[N:21][CH:22]=2)=[CH:14][CH:13]=[C:12]([CH2:23][CH3:24])[N:11]=1)=[O:9])C.[NH2:25][C:26]1[S:27][CH:28]=[C:29]([CH3:31])[N:30]=1>>[CH3:31][C:29]1[N:30]=[C:26]([NH:25][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:22]=[N:21][CH:20]=[N:19][CH:18]=3)=[CH:14][CH:13]=[C:12]([CH2:23][CH3:24])[N:11]=2)=[O:9])[S:27][CH:28]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 16682925TrimethylaluminumHCID 58368048HCID 58368048, compound

Product 1

HCID 11602545HCID 11602545, compound

Procedure

The Al(Me)3-catalyzed reaction of 6-Ethyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid ethyl ester and 2-Amino-4-methyl-thiazole in accordance with the general method of Example 78, step 2 yielded the title compound as a yellow cristalline solid, MS (ISP): m/e=340.9 (M+H+).

Sources & evidence

ORD record
ord-5e4bcc6606b74b84b250c9baa5683674
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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