tert-Butanol → tert-Butyl (2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-yl)carbamate
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2(C(O)=O)[CH2:11][C:10]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:9]2)=[CH:4][CH:3]=1.CC[N:21]([CH:25](C)C)C(C)C.[C:28]([OH:32])([CH3:31])([CH3:30])[CH3:29].C1C=CC(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:40])=CC=1.C(=O)(O)[O-].[Na+]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([NH:21][C:25](=[O:40])[O:32][C:28]([CH3:31])([CH3:30])[CH3:29])[CH2:9][C:10]3([O:12][CH2:13][CH2:14][O:15]3)[CH2:11]2)=[CH:6][CH:7]=1Participants
6
Conditions
- Temperature
- 100 °C
Procedure
To a solution of 2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octane-2-carboxylic acid (1-4) (40.7 g, 130 mmol) and DIPEA (22.7 mL, 130 mmol) in tert-butanol (231 mL, 3.25 mol) was added DPPA (35.8 g, 130 mmol) and the reaction was heated to 100° C. overnight under N2. The reaction mixture was poured into saturated sodium bicarbonate, extracted with EtOAc, dried over sodium sulfate, filtered and concentrated. The crude residue was purified by column chromatography eluting with 7-50% EtOAc/Hexane. The appropriate fractions were combined and the solvent removed in vacuo to give tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate (1-5). MS (M+H)+: 385.
Workup
- extractionextracted with EtOAc
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
- customThe crude residue was purified by column chromatography
- washeluting with 7-50% EtOAc/Hexane
- customthe solvent removed in vacuo
Sources & evidence
- ORD record
- ord-77dac16fb8b5450e9ca5b23c8ceedeef
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08207169B2
Reaction notes
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