Hydroxyamine hydrochloride → 5-[(1E)-1-hydroxyimino-3-methyl-2,3-dihydroinden-5-yl]-1-methylpyrrole-2-carbonitrile

HRID 2219811Notes

Reaction equation

HRID 2219811 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[C:12](=O)[CH2:11][CH:10]3[CH3:17])=[CH:5][CH:4]=[C:3]1[C:18]#[N:19].Cl.[NH2:21][OH:22]>>[OH:22]/[N:21]=[C:12]1\[CH2:11][CH:10]([CH3:17])[C:9]2[C:13]\1=[CH:14][CH:15]=[C:7]([C:6]1[N:2]([CH3:1])[C:3]([C:18]#[N:19])=[CH:4][CH:5]=1)[CH:8]=2

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 249866681-methyl-5-(3-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)-1H-pyrrole-2-carbonitrile

Product 1

HCID 162263655-[(1E)-1-hydroxyimino-3-methyl-2,3-dihydroinden-5-yl]-1-methylpyrrole-2-carbonitrile

Procedure

The title compound was prepared from 1-methyl-5-(3-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)-1H-pyrrole-2-carbonitrile and hydroxylamine hydrochloride according to the procedure described in example 1. MS m/z 266; HRMS: calcd for C16H15N3O+H+, 266.12879; found (ESI, [M+H]+), 266.1299; Anal. Calcd for C16H15N3O: C, 72.43; H, 5.70; N, 15.84. Found: C, 71.86; H, 6.31; N, 15.47.

Sources & evidence

ORD record
ord-516ad9cca6e94f099fa95421c1b20ba9
Source dataset
uspto-grants-2008_08
Patent number
US07414142B2

Reaction notes

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